Abstract: Under complex dynamic constraints,a three-dimensional pursuit-evasion game between missile and airplane is studied.Based on the co-evolutionary theory and the mathematical models of missile and airplane dynamics,mixed pursuit-evasion strategies are designed for both players to guarantee the evolution process.In accordance with the simple fitness and the sharing fitness,a mixed fitness is developed to evaluate game results.Then a co-evolutionary algorithm is applied to evolve the strategies of both players concurrently.The influences of different fitness on evolution results are compared.Simulation results show that the evolved airplane can effectively evade the proportionally guided pursuers.And in the co-evolutionary process,the strategies of both players are improved.