Abstract: With respect to the strong uncertain property of the hypersonic gliding vehicles,the robust control method based on H∞ mixed sensitivity is adopted to design the control system. At first, the uncertain parameters are analyzed using the sensitivity analysis method based on worst case gain (WCG) and the principal uncertain parameters which can stand for the uncertainty of the original model are obtained. Then, according to the results of the parameter analysis, the weighting functions of the robust controller are selected, which contribute to the completion of the controller design. Finally, nonlinear simulations of the control system on characteristic point and parameter deviating are carried out, and the dynamic performance and robustness of the control system are examined. The results validate the effectiveness of the analysis and design method of the control system.