The numerous factors have an impact on the performance of guidance and control system for hypersonic vehicle. Thus, a great quantity of simulation experiments is needed to obtain the accurate evaluation conclusion, leading to the poor evaluation efficiency. To slove this problem of performance evaluation, a performance evaluation method, applicable to hypersonic vehicles is investigated. Firstly, the closedloop vehicle model containing the guidance and control law is built and factors affecting the vehicle are analyzed. Furthermore, the main influencing factors are selected as experimental factors and the sampling scheme is obtained in the sampling space based on the optimal Latin hypercube experiment design method. In conjunction with simulation data, the evaluation conclusion is gotten. Finally, the instance of performance evaluation verifies that the proposed approach is effective and feasible.