An anti-windup control strategy based on the extended state observer is designed for a class of sliding skin morphing wing subject to strong nonlinearity, uncertainties, disturbances and actuator saturation. The multiple uncertainties of the morphing wing are treated as an extended state, and estimated in the designed observer. Then the extended state is compensated in the controller in real time. The domain of attraction subject to actuator saturation condition is given based on linear matrix inequality. The simulation results demonstrate the effectiveness of the proposed method, and that the morphing wing can complete morphing instructions despite of the uncertainties and actuator saturation.