Abstract: The problem of operation effectiveness analysis of anti-TBM weapon systems based on space-based information supporting is studied using system effectiveness analysis(SEA) method.Based on the anti-TBM operation workflow of weapon systems with space-based information support and their mutual connections,the algorithms of measure of performance(MOP),measure of mission(MOM),and measure of effectiveness(MOE) of weapon systems are designed.These algorithms effectively integrate the measure of performance and measure of mission of weapon systems with the operation environment,it is able to analyze the support effect of space-based information perfectly for the anti-TBM operation of weapon systems and the sensitivities of the key parameters.A numerical example is given to illustrate the gained outcomes.